Speakers

Keynotes

Prof. Katharina Landfester | Max-Planck Institute
Polymeric synthetic cells for cascade reactions

Since many years, there is a quest for minimal cells in the field of synthetic biology, potentially allowing a maximum of efficien­cy in biotechnological processes. Our aim is at developing to-called “protocells” consisting of giant polymersomes and engulfed nanocontainers with incorporated functions, such as energy production and the control of transport properties through nanomembranes.

We have designed and developed nanocapsules that act as cell-like compartments and can be loaded with enzymes or synthetic catalysts for synthetic biology and chemistry. Based on the selective co-compartmentalization of enzymes we were able to favor a desired pathway in competitive cascade reactions and increase the entire reaction kinetics of sequential cascade reactions. We also present an artificial enzyme combination to produce NAD⁺ continuously; no additional organic substrates are required once a minimal amount pyruvate is supplied, and no accumulation of byproducts is obtained. Three enzymes are covalently encapsulated into a silica nanoreactor to develop the continuous NAD+ regeneration system. The enzymes retain their activity inside of the nanoreactors and are protected against proteolysis and heat.

Prof. Costantino Creton | ESPCI Paris
Role of dynamic bonds in rheology and fracture of hydrogels

Soft matter is characterized by weak interactions which, as a result, lead to dynamic (liquid-like) behavior. On the other hand Macromolecules are strong along their backbones and weak in their intermolecualr interactions. In this work we explore a combination of both by investigating the properties of a covalently crosslinked hydrogel infused with metal coordination dynamic bonds. The divalent metal can form a coordination bond with an imidazole group included in the back bone of the polymer. Depending on the nature of the metal the strength and lifetime of the bond varies. We will discuss the effect of these dynamic bonds on the rheological and fracture properties of the gel.

Invited speakers

Prof. Bram Vanderborght | Vrije Universiteit Brussel
Self healing materials for sustainable soft robots

Soft robots, inspired by the pliability of biological systems, often face the issue of being prone to damage. However, biological entities have self-repair capabilities—a feature we’ve emulated in our soft robots to foster renewed confidence in their reliability. Our technological advancements enable these robots to self-heal, enhancing their durability and extending their operational lifespan. This innovation not only increases reuse but also allows for recycling, contributing to sustainable manufacturing practices.

We’ve revolutionized the entire production process by developing materials that surpass mere coatings; they form structural 3D components with diverse mechanical, conductive, and magnetic qualities. These materials are compatible with multi-material printing as well as extrusion and molding techniques—processes typically unsuitable for traditional network polymers due to thermal limitations and delamination risks at material interfaces. Our breakthroughs include self-repairing robotic grippers and integrated sensors that not only detect but also respond to damage.

Dr. Matt Baker | Maastricht University
Macromolecular design of polymeric networks to create dynamic biomaterials

Creating living objects that merge cells and materials could revolutionize human body treatments and usher in a new future for materials. A significant challenge is mimicking the 3D environment essential for tissue and cell communication. Our goal is to enhance tissue engineering by integrating macromolecular design with cell culture and biofabrication technologies.

Our lab's materials, created through organic and polymer synthesis, emphasize dynamic interactions and light-responsive reactions. These materials offer precise control over the dynamics of artificial extracellular matrices. For instance, by adjusting the hydrophobicity and reactivity of supramolecular units, we optimize viscoelastic timescales for bioprinting robust hydrogels that support cell viability. Similarly, analyzing dynamic covalent hydrogels reveals unexpected behaviors beyond traditional theories. This work aims to unlock new material properties for soft matter, ultimately advancing biomedical material translation in the future.

Dr. Martijn Cox | CTO at Xeltis
Supramolecular polymer materials bring restorative heart valves and blood vessels to patients

Xeltis is an Eindhoven-based medical device company developing artificial vessels and valves that are gradually replaced by the patients’ own living healthy tissue. The natural creation of living and long-lasting vessels reduces the risk of thrombosis, stenosis, calcification and infection which are often the root cause of failure.

Xeltis makes use of supramolecular polymers that are electrospun into porous implants that allow patient-own tissue to gradually fill the pores of the bioabsorbable implant. The ambition at Xeltis is to improve standards of care for millions of patients who undergo vascular surgery every year, including hemodialysis access and coronary arterial bypass surgery. More than 100 patients have already been provided with Xeltis' implants as part of several ongoing clinical studies.

Van Arkel Award Lecture

Dr. Laura de Kort
A Dynamic Duo; Fast ion conduction in metal hydride/oxide nanocomposites

The biennial KNCV-Van Arkel prize 2022-2023 has been awarded to Dr. Laura de Kort, who completed her PhD under the supervision of Dr. Peter Ngene and Prof. Dr. Petra de Jongh at Utrecht University. Dr. De Kort was selected from a competitive field of four other outstanding candidates, all of whom produced exceptional PhD theses and published extensively in prestigious academic journals on topics such as polymer membranes, stimuli-responsive hydrogels, supramolecular polymers, and thermoplastic liquid crystals. Dr. De Kort distinguished herself through her groundbreaking contributions to fundamental insights in inorganic and physical chemistry, the key disciplines the KNCV aims to advance with the Van Arkel Prize.

Dr. De Kort’s thesis addresses the development of novel solid inorganic electrolytes with high ionic conductivity, a crucial component in the creation of solid-state batteries that offer enhanced safety compared to conventional lithium-ion batteries, which use flammable organic solvent-based electrolytes. Her pioneering findings not only pave the way for the rational design of new solid-state batteries, but also for the development of inorganic solid-state electrolytes, such as proton and hydride conductors, with potential applications in next-generation fuel cells, electrolyzers, sensors, and electrocatalysts. As such, her research significantly contributes to society's transition towards sustainable energy solutions.